A randomized pilot clinical trial of early coronary angiography vs no early coronary angiography for post-cardiac arrest patients without ST-segment elevation: The PEARL study
Circulation Nov 01, 2020
Kern KB, Radsel P, Jentzer JC, et al. - Researchers assessed the efficacy as well as the safety of early coronary angiography and investigated the prevalence of acute coronary occlusion among resuscitated out-of-hospital cardiac arrest patients without ST-segment elevation. In this multi-center study, 99 patients were enrolled, including 75 with initially shockable rhythms. The patients who were randomized to early coronary angiography were 49 in total. Early coronary angiography was not related to any significant increment in survival or adverse events. A culprit vessel in 47% was detected by early coronary angiography, with overall 14% of patients receiving early coronary angiography having an acutely occluded culprit coronary artery. Based on the findings of this study combined with previous clinical trials, early coronary angiography was not supported for comatose survivors of cardiac arrest without ST elevation. If early identification of occluded potential culprit arteries results in interventions that improve outcomes needs additional inquiry.
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