Caltagirone R, et al. - In a randomized controlled trial, a comparison was performed between a needle-free jet-injection system (J-Tip) with 1% buffered lidocaine and topical anesthetic (TA) cream for local anesthesia in infant lumbar punctures (LPs). As per findings, J-Tip was not superior to topical anesthetic cream as measured by pain control or physiologic changes. The success rate was twice in infant LPs performed with J-Tip.