Maatman RC, et al. - Researchers sought to determine the efficacy of pulsed radiofrequency (PRF) in anterior cutaneous nerve entrapment syndrome [ACNES] via performing a multicenter, randomized, nonblinded, controlled proof-of-concept trial in 66 patients. A 6-minute cycle of PRF treatment was provided to 33 patients first, while the allocation of the other 33 to an immediate neurectomy procedure was done. Using a numeric rating scale (NRS, 0 [no pain] to 10 [worst pain possible]), they recorded pain. They defined successful treatment as >50% pain reduction. Twelve of 32 (38%) of the PRF group and 17 of 28 (61%) of the neurectomy group reported achievement of treatment success. These findings suggest the possible efficacy of PRF and its value as a minimally invasive treatment option. Hence they suggest considering PRF in patients who failed conservative treatment options before proceeding to a neurectomy procedure. Compared with PRF, anterior neurectomy may provide greater pain relief in ACNES patients, however, a discussion is recommended regarding potential complications associated with surgery.