Suter VGA, et al. - In this randomized controlled trial, researchers compared excisional biopsies of fibrous hyperplasia performed using a CO₂ laser (140 Hz, 400 μs, 33 mJ), Er:YAG laser (35 Hz, 297 μs, 200 mJ, air–water cooling), or scalpel (15c blade). Duration of the intervention, intraoperative bleeding, need for electrocauterization and/or suturing, postoperative side effects, complications, pain, and intake of analgesics were recorded clinical parameters. Compared to the scalpel, the duration of the intervention was significantly shorter for both lasers. With the CO₂ laser, intraoperative bleeding occurred less frequently. For excisional biopsies of small lesions in the oral mucosa, CO₂ laser, Er:YAG laser, and scalpel are all suitable. While postoperative morbidity of the patient is similar, the ideal tool can be selected based on the preferred surgical advantages for the individual situation.