Geller JI, Cost NG, Chi YY, et al. - Researchers performed AREN0321, the first prospective clinical study of pediatric and adolescent renal cell carcinoma (RCC) establishing epidemiological, treatment, and outcome data and confirming that patients with completely resected pediatric RCC, including lymph node–positive disease (N1), have a favorable prognosis without adjuvant therapy. Among 68 enrolled patients (39 of whom were male; median age of 13 years [range, 0.17‐22.1 years]), classification of stage was done according to the American Joint Committee on Cancer TNM stage seventh edition: stage I was reported in 26 patients, stage II in 7 patients, stage III in 26 patients, and stage IV in 8 patients, and was not available in 1 patient. Resection of all known sites of disease was undertaken in 60 patients, including 2 patients with stage IV disease. Outcomes suggest that complete resection of RCC without adjuvant therapy can lead to favorable short‐term outcomes in children and adolescents, independent of lymph node status.