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A prospective study investigating gross motor function of children with cerebral palsy and GMFCS level II after long-term Botulinum toxin type A use

BMC Pediatrics Jan 16, 2020

Valentine J, Davidson SA, Bear N, et al. - Prospective cohort study of children with Cerebral Palsy in the birth years 2000–2009 attending a tertiary level service for children with Cerebral Palsy who’s first recorded Gross Motor Function Classification System level was II, experts intend to contribute to the knowledge base on the long-term consequences of evidence-based medical interventions utilized to improve gross motor function in children and adolescents with Cerebral Palsy. They involved 28 out of 40 children, who were eligible for the study. The Botulinum toxin A treatment for this cohort such as the total number of lower limb Botulinum toxin A injections 11, total dose of Botulinum Toxin A per lower limb treatment 6.95 u/kg and the dose of Botulinum Toxin u/kg/muscle 2.95. It was confirmed that doses of Botulinum Toxin A was given repeatedly to children with Cerebral Palsy, Gross Motor Function level II treated at a young age within an integrated comprehensive service, maintain or improve their functional motor level at a later age.
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