Nakamura Y, Ishitsuka Y, Sasaki K, et al. - Researchers conducted this prospective, phase 2 clinical study with the aim to examine the safety and efficacy of negative pressure closure (NPC) for the stabilization of split-thickness skin graft (STSG) in large or muscle-exposing defects. They applied NPC for skin graft stabilization in seven patients who had received wide excision of malignant tumors resulting in muscle-exposed skin defects and undergone meshed STSG. At postoperative day 7 and 10, the mean survival rate of 98.7% (range 97–100) and 96.5% (range 89.4–98.4), respectively, was recorded for the skin graft. This study yields further evidence supporting the safety and efficacy of NPC for STSG stabilization in patients with large or muscle-exposing skin defects.