Bahig H, Ng SP, Pollard C, et al. - In this investigation involving 39 individuals, researchers reported cancer control outcomes and health-related quality of life (HRQoL) results after highly conformal skull-based re-irradiation (re-RT). Study participants included patients who planned for curative intent re-RT to a recurrent or new skull base tumor. Utilizing the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires, HRQoL were evaluated. Participants in the study were treated with stereotactic body RT or intensity modulated RT. At 1-year, progression-free survival was 71%. At the end of RT, there was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ), followed by recovery to baseline on subsequent follow-ups. Clinically, at 12 months, subjective emotions were improved with patients reporting feeling less tense/nervous. Findings suggested an association of conformal skull base re-RT with mild immediate deterioration in physical function followed by rapid and sustained recovery.