Lyapichev KA, Piña-Oviedo S, Medeiros LJ, et al. - The gross features of the capsules, as well as the presence, extent, and depth of tumor cells on the luminal side and number of sections involved by lymphoma, were discovered by a review of routine stains and CD30 immunohistochemistry by the experts in order to investigate complete capsulectomies without distinct gross lesions from individuals with breast implant anaplastic large cell lymphoma. Fifty individuals with breast implant anaplastic large cell lymphoma who had complete capsulectomies were recognized. In all 32 cases with available information, the implants were textured. Anaplastic large cell lymphoma was discovered in 44/50 capsules and no tumor was ascertained in six individuals who had lymphoma cells only in the effusion. The median number of sections analyzed was 20, the median percentage of sections included by tumor was 6%, and the median percentage of sections affected by lymphoma was 10%. In 18/50 individuals, invasion deep into or through the capsule was distinguished. A spectrum of involvement was recognized and a protocol for handling, sampling and reporting these cases was proposed, in individuals with breast implant anaplastic large cell lymphoma without a grossly identifiable tumor. Moreover, the number of sections to eliminate the presence of lymphoma with more than 95% conviction was established by a mathematic rationale.