Kone LB, et al. - Since clinically relevant postoperative pancreatic fistula (CR-POPF) remains a major cause of morbidity in patients undergoing pancreatic surgery, researchers ascertained if there is any difference in CR-POPF with a Duct-to-Mucosa (DTM) vs an Invagination (IG) pancreaticojejunostomy (PJ). From the American College of Surgeons (ACS) National Surgical Quality Improvement Program 2014–2017 databases, demographic, perioperative, intraoperative, and postoperative data were captured. In total, 12,361 pancreaticojejunal anastomoses were performed with 11,168 patients experiencing DTM and 1,193 undergoing IG following pancreaticoduodenectomy. For patients with average size pancreatic ducts, DTM or IG technique were not related to CR-POPF. However, in patients with large pancreatic duct diameter (> 6 mm), DTM is preferable.