Kommalapati A, et al. - Experts aimed to generate and internally validate a prognostic scoring model to forecast long-term overall survival (OS) for de novo stage IV breast cancer (BC) patients treated with locoregional treatment (LRT). LRT seems to be related to a better OS in specific subgroups, although firm treatment-related conclusions cannot be made due to the retrospective nature of the study. The findings suggested that this prognostic scoring system can assist oncologists in predicting the prognosis in de novo stage IV BC patients treated with LRT.