Onoe S, Yokoyama Y, Kokuryo T, et al. - Researchers here examined the utility of systematically chosen nonanatomic biomarkers in stratifying the probability of surviving pancreatic carcinoma. Among 187 consecutive patients that underwent surgical resections for pancreatic carcinoma, they identified poor survival in correlation with two independent risk factors: neutrophil-to-lymphocyte ratio ≥ 3.0 (hazard ratio, 1.54) and prognostic nutritional index < 36 (hazard ratio, 1.60), and with high carbohydrate antigen 19-9 levels (≥ 37 IU/mL). Researchers constructed a presurgical nonanatomic scoring system (range, 0−2): 0 points for no risk factors, 1 point for 1 or 2 nutritional risk factors, and 1 point for carbohydrate antigen 19-9 ≥ 37 IU/mL. A decrease in survival rate at 3 years was evident with increasing scores. Findings overall suggest that integration of neutrophil-to-lymphocyte ratio and prognostic nutritional index with carbohydrate antigen 19-9 levels could successfully stratify survival in pancreatic carcinoma.