Ribeiro HC et al. – The study was aimed to investigate possible alterations in the serum lipid profile of euthymic patients with bipolar disorder (BD) type I compared with healthy controls (HC). In conclusion, serum lipid profiles were abnormal in patients with BD and phosphatidylinositols was found to be the most altered lipids.

Methods

• A total of 35 individuals (male and female) were included, with 14 diagnosed and treated as BD patients (BD group) and 21 as HC.
• In order to confirm diagnosis, psychiatric comorbidities, and to estimate the severity of manic and depressive symptoms, clinical assessment was done using the Structured Clinical Interview for DSM–IV Axis I Disorders, Young Mania Rating Scale, and 17–items of Hamilton Depression Rating Scale data.
• Lipid profile was analyzed using ultra–high–performance liquid chromatography coupled with high resolution mass spectrometry.

Results

• Multivariate statistical analyses revealed that 121 lipids were significantly different between the BD and HC groups.