A population-level analysis of the differing effects of rheumatoid arthritis and spondyloarthritis on peripartum outcomes
The Journal of Rheumatology Feb 13, 2020
Keeling SO, et al. - This study was sought to compare the impacts of rheumatoid arthritis (RA) and spondyloarthritis (SpA) on maternal and neonatal outcomes at a population level. Researchers collected a contemporary pregnancy cohort of 312,081 women and corresponding birth events for the province of Alberta from the random selection of 1 live birth event per woman. Individuals were classified into 3 groups [no inflammatory arthritis (no IA, n = 308,989), RA (n = 631), and SpA (n = 2,461)]. The neonatal outcomes, comorbid conditions, and medication use were compared among the 3 groups. Multivariable logistic regression models were applied to evaluate the independent relationship between RA and SpA, relative to no IA, and the outcomes of small for gestation age and hypertensive disorders during pregnancy. The results of this study displayed that, a higher risk of worse maternal and neonatal outcomes were found in women with RA, whereas the risk of these events is similar between women with and without SpA.
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