Kempe-Teufel D, et al. - A sum of 2789 candidates without diabetes of the Tubingen Family study of type 2 diabetes characterized by oral glucose tolerance tests, were studied to estimate the general single nucleotide polymorphisms (SNPs) in 48 lipolysis-, to form polygenic risk scores of lipolysis-associated SNPs, and also to examine their influences on the distribution of body fat, glycemia, insulin sensitivity, insulin secretion, and proinsulin conversion. They recognized insulin-sensitivity–independent nominal relations of SNPs in 10 genes with plasma free fatty acids (FFAs), in 7 genes with plasma glycerol and in 6 genes with both, plasma FFA and glycerol. An association of score formed of the latter SNPs (in ADCY4, CIDEA, GNAS, PDE8B, PRKAA1, PRKAG2) with plasma FFA and glycerol measurements, visceral adipose tissue mass, and proinsulin conversion was also noticed.