Manousaki D, Forgetta V, Keller‐Baruch J, et al. - Since some widely prescribed medicines are associated with increased risk of osteoporotic fractures, however, fracture risk stratification using skeletal measures is not often conducted to identify those at risk until such medicines are prescribed, researchers ascertained if a genomically predicted skeletal measure, speed of sound (gSOS) from heel ultrasound, which was developed in 341,449 people from UK Biobank and tested in a separate subset consisting of 80,027 people, is an independent risk factor for fracture in users of fracture‐related drugs (FRDs). For this analysis, they first evaluated 80,014 UK Biobank candidates (including 12,678 FRD users) for incident major osteoporotic fracture (MOF, N = 1,189) and incident hip fracture (N = 209). FRD users with gSOS below vs above the mean had a 54% higher adjusted MOF odds and a 2‐fold hip fracture adjusted odds increased. Therefore, the authors demonstrated that genomically predicted heel SOS is independently linked to incident fracture among users of FRD.