Melendez E, et al. - Via this prospective observational pilot study enrolling children 0–17 years old with a diagnosis of septic shock, researchers assessed if Emergency Department amino-terminal pro-B-type natriuretic peptide is associated with worse outcomes and severity of illness. In participants, each decile change increase in amino-terminal pro-B-type natriuretic peptide was noted to be associated with a change in ICU length of stay by 8.7%, hospital length of stay by 5.7%, organ dysfunction by 5.1%, a higher inotropic score at 12, 24, and 36 hours, and longer time requiring vasoactive agents. A significant correlation was identified between baseline amino-terminal pro-B-type natriuretic peptide and the Pediatric RISk of Mortality 3 score.