Vieira CS, et al. - Researchers assessed 20 women with epilepsy (WWE) ages 18 to 45 years with well-controlled seizures and stable antiepileptic drug regimens initiating a 52-mg levonorgestrel (LNG)-intrauterine device (IUD) (20 mcg/d initial release), for LNG concentrations, bleeding patterns and endometrial thickness. Blood collection and endometrial thickness measurement were done before IUD placement and 21 days, 3 months and 6 months thereafter. Analysis revealed stable total LNG concentrations and decreasing endometrial thickness and bleeding over the first 6 months of use among WWE initiating the LNG-IUD, similar to that observed in women without epilepsy.