Turkistani S, Sugita BM, Fadda P, et al. - Researchers sought to determine the global expression profile of microRNAs (miRNAs), their influence on cellular signaling pathways, as well as their link with poor prognostic parameters among African-American (AA) patients suffering from triple negative breast cancer (TNBC). They found that a panel of eight, 23 and 27 miRNAs were related to tumor size, lymph node (LN), and recurrence (REC) status, respectively. A robust discriminatory power based on tumor size (AUC = 0.917), LN (AUC = 0.945) and REC (AUC = 0.981) status was demonstrated by integrated ROC analysis of two (miR-2117, and miR-378c), seven (let-7f-5p, miR-1255b-5p, miR-1268b, miR-200c-3p, miR-520d, miR-527, and miR-518a-5p), and three (miR-1200, miR-1249-3p, and miR-1271-3p) miRNAs, respectively. Overall, miRNA deregulated expression was revealed as a relevant biological factor, and a poor prognosis in TNBC of AA patients can be seen in relation to miRNA deregulated expression as it confers to their TNBC cells aggressive phenotypes that are reflected in the clinical features assessed in this study.