Austin DC, et al. - Patients (n = 217) who underwent TKA who completed the Patient-Reported Outcomes Measurement Information System-10 (PROMIS-10), the Knee Disability and Osteoarthritis Outcomes Score Junior (KOOS Jr), and modified single assessment numerical evaluation (M-SANE) (modified-SANE) assessments both preoperatively and postoperatively were analyzed by the researchers in order to assess the utility of the one-question, M-SANE score in TKA patients in comparison with legacy patient-reported outcome measures (PROMs). Floor and ceiling effects of the M-SANE were greater than other PROMs but still relatively low. A moderate to strong association at nearly all time points between the M-SANE and KOOS Jr was found. A weak relationship between the M-SANE and PROMIS physical component summary at the preoperative assessment, though a strong association at 1-year follow up was observed. The long-term responsiveness of the M-SANE to TKA was similar to both the KOOS Jr and PROMIS physical component summary. Bland-Altman plots illustrated that the M-SANE and KOOS Jr capture combined knee pain and functionality separately. Hence, in TKA patients, the M-SANE score was similar to confirmed multiple-question PROMs. For evaluation of patients undergoing TKA, the exhibited validity of the M-SANE, as well as its similar responsiveness to more lengthy PROMs, reflects its use as a one-question PROM.