Roseweir AK, et al. - Considering the significance of establishing the role of epithelial-mesenchymal transition (EMT) within the tumor center and its effect on the tumor microenvironment on prognosis and therapeutic intervention in colorectal cancer (CRC), researchers examined five immunohistochemical EMT markers within the tumor center on 185 Stage II/III CRC patient tissue microarrays. As per findings, patients’ survival could be stratified using a novel combined EMT score in Stage II/III CRC. Further, the score was noted to be associated with key factors of tumor metastasis. These findings suggest the utility of combined EMT score in recognizing patients at risk of micrometastases and for whom standard adjuvant therapy, possibly combined with EMT blockade, could be useful. Independent of TNM-stage the combined EMT score was linked with cancer-specific survival.