Engeroff P, et al. - In humans, the mechanism by which CD23-expressing cells take up IgE-immune complexes (IgE-IC) and process them is not well understood. Researchers addressed this question in this current study and compared the fate of IgE-IC in human B cells and in CD23 expressing monocyte-derived dendritic cells (moDCs) that represent classical antigen presenting cells (APCs). Furthermore, they studied IgE-dependent antigen presentation in both cell types. As per findings, B cells act as carriers transferring antigen to more efficient APCs such as dendritic cells, as well as, can directly promote DC maturation and thereby enhance T cell stimulation. The findings of this investigation argue for a new model in which human B cells promote specific T cell proliferation upon IgE-IC encounter.