Khan IM, Gjuka D, Jiao J, et al. - Since osteopontin (OPN) was previously established as an encouraging biomarker for the early detection of HCC, researchers sought to further validate the its performance and find fatty acids (FAs) that could improve its performance in risk assessment of HCC in cirrhotic patients. One hundred three cirrhotic patients under surveillance were analyzed. There were statistical differences in the abundance of 11 FAs (four long-chain saturated FAs (SFAs), four n-3 polyunsaturated FAs (PUFAs), and three n-6 PUFAs) between patients who developed HCC and those who did not. A panel of 4 high-performing markers has been established that could be useful in the early detection of HCC in patients with cirrhosis who are under surveillance.