van der Lee SJ, Conway OJ, Jansen I, et al. - Experts examined the influence of the rs72824905-G (minor allele in the phospholipase Cγ2 (PLCG2) gene which was formerly correlated with a decreased Alzheimer disease [AD] risk) on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals, and 149,290 study-matched controls, since the role of PLCG2 in immune system signaling implies that it may also guard against other neurodegenerative diseases and possibly correlates with longevity. The correlation of rs72824905-G with decreased AD risk was replicated and a relationship with diminished risk of dementia with Lewy bodies and frontotemporal dementia was seen. On Parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis risks, no evidence for an impact regardless of adequate sample sizes was observed. Conversely, the rs72824905-G allele was affiliated with an increased possibility of longevity. With both dementia and longevity, by-proxy analyses, strengthened the relationship, in the UK Biobank. Therefore, rs72824905-G had a protective influence against multiple neurodegenerative diseases symbolizing shared aspects of disease etiology. Also, the conclusions benefited studying the PLCγ2 pathway as drug-target.