Ber Y, Segal N, Tamir S, et al. - In this study, the detection rate of clinically-significant prostate-cancer (csPCa) within an index lesion between transrectal (TR) and transperineal (TP)-fusion was compared. Researchers designed a prospective, noninferiority, and within-person trial including a sum of 77 individuals for MRI–US-fusion with a discrete MRI PI-RRAD ≥ 3 lesion. They determined a dominant index lesion for each subject and sampled it by TR and TP-fusion during the same session. They randomized the order of biopsies and equipment was reset to avoid chronological and incorporation bias. Using Navigo fusion software (UC-Care, Yokneam, Israel), all biopsies were performed. They applied a noninferiority margin of 10% and a one-sided alpha level of 5%. For the detection of csPCa within MRI-visible index lesion, TP-fusion biopsies were found to be noninferior and superior to TR-fusion biopsies. When choosing biopsy method, centers experienced in both TP and TR-fusion should consider these results.