Sampson M, Ling C, Sun Q, et al. - This study sought to design a more accurate low-density lipoprotein cholesterol (LDL-C) equation for individuals with LDL-C level and/or hypertriglyceridemia. Between January 1, 1976, and June 2, 1999, researchers included a total of 8,656 patients data on LDL-C levels and other lipid measures seen at the National Institutes of Health Clinical Center, were examined by the β-quantification reference method (18 715 LDL-C test results) and were randomly classified into equally sized training and validation data sets. Applying TG and non–high-density lipoprotein cholesterol as independent variables, they applied multiple least squares regression to establish an equation for very-low-density lipoprotein cholesterol, which was then applied in a second equation for LDL-C. Compared with the standard lipid panel, the new equation can be readily implemented by clinical laboratories with no additional costs. It will support for more accurate estimation of LDL-C level in individuals with low LDL-C levels and/or hypertriglyceridemia (TG levels, ≤800 mg/dL) and thus should increase the use of LDL-C level in cardiovascular disease risk management.