de Kok MJ, Schaapherder AF, Mensink JW, et al. - Researchers sought to determine the consequence of early graft loss (EGL) via performing systematic evaluation of its impact in an observational study that included all 10, 307 deceased-donor kidney transplantations performed in The Netherlands between 1990 and 2018. Graft loss within 90 days defined EGL; its incidence in primary transplantation was 8.2% (699/8,511). Graft rejection (30%), primary non-function (25%), and thrombosis or infarction (20%) were the main causes identified. EGL after kidney transplantation was identified as a medical catastrophe with high mortality rates, low relisting rates, and increased risk of recurrent EGL following re-transplantation. Findings thereby imply involvement of convergence of risk factors in recipients with EGL in detrimental outcomes. As minimal impact was observed of the 8.2% incidence of EGL on population mortality, this incidence is identified as acceptable.