Yadav K, et al. – Researchers investigated the efficacy of an antibiotic stewardship intervention adapted for acute care ambulatory settings (adapted intervention) vs a stewardship intervention that additionally incorporates behavioral nudges (enhanced intervention) in reducing inappropriate prescriptions in acute respiratory infection (ARI) in this pragmatic, cluster-randomized clinical trial. Providers at three academic health systems, comprising five adult and pediatric emergency departments (ED) and four urgent care centers (UCCs), received either the adapted or the enhanced intervention. Across the nine cluster sites, 44,820 ARI visits were reported among 292 providers. Observations suggested the feasibility and efficacy of implementation of antibiotic stewardship for ARI in the ED and UCC settings. No higher efficacy of more intensive behavioral nudging methods was evident in high-performance settings.