Kallewaard JW, et al. - Researchers sought to confirm the findings from a study published in PAIN in 2010 indicating intradiscal methylene blue (MB) injections to have remarkable efficacy compared to placebo on pain intensity in patients with chronic discogenic low back pain (CD-LBP) via replicating the design of the previously published study and performing a multicenter, double-blind, randomized, placebo-controlled trial. Lidocaine hydrochloride injections were administered in both groups for pain associated with the procedure. Eighty-four patients with CD-LBP were included. Treatment success was noted in 14 (35%) in the MB plus lidocaine group compared with 11 (26.8%) in the control group who received placebo plus lidocaine. Findings do not confirm the better efficacy of intradiscal MB injections in significantly reducing pain in patients with CD-LBP 6 months after treatment compared with placebo. In contrast to the previously published study, treatment success was reported in one-quarter of patients receiving only lidocaine injections. The recommendation of using intradiscal MB injections for patients with CD-LBP is thus not supported in this work.