Ishikawa M, Kasamatsu T, Tsuda H, et al. - Researchers performed a multicenter, retrospective study examining the clinical behavior of neuroendocrine tumors (NETs) of the uterine cervix among 193 patients. With respect to the new International Federation of Gynecology and Obstetrics staging system, the prognosis of NETs was assessed. In addition, they compared the clinical response to different chemotherapy regimens, and compared different histological subtypes of NETS. The analysis revealed that for NET of the cervix, independent prognostic factors are locally-advanced and extra-pelvic disease. Good responses to etoposide-platinum or irinotecan-platinum regimens but not to taxane-platinum regimen were observed among cases with high-grade neuroendocrine carcinomas (HGNEC: both small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma). Less response to chemotherapy and a prognosis identical to HGNEC were evident for atypical carcinoid tumors.