Kemp JP, et al. - In 15-year-olds from the Avon Longitudinal Study of Parents and Children, researchers investigated connections between a metabolic screen focusing on fat metabolism and peripheral quantitative computed tomography (pQCT) measures of the mid-tibia. To study links between metabolic measures and periosteal circumference (PC), cortical thickness (CT), and cortical bone mineral density (BMD_C), ordinary least squares linear regression was utilized. Participants in the study were 1121 subjects (mean age 15 years). After adjustment for age, sex, and Tanner stage, several metabolites related to lipid and cholesterol metabolism were linked to PC, CT, and BMD_C. In addition, citrate exhibited evidence of association with PC and strength strain index. According to findings, circulating citrate levels were inversely related to BMD_C and positively related to PC in adolescents, reflecting associations with higher bone turnover.