Moscarella E, Pampena R, Palmiotti G, et al. - In this systematic review and meta-analysis, researchers examined the impact of different biopsy procedures on melanoma recurrence rates and melanoma-related survival (MRS). The meta-analysis included clinical trials, observational cohort studies, and case-control studies reporting the absolute number of recurrences and/or melanoma-related deaths in patients undergoing a partial or excisional melanoma biopsy. Upon analysis, forest plot displayed no difference in the risk of dying due to melanoma-related causes among patients undergoing partial biopsy vs excisions biopsy. In special situations like large primary tumors located in surgically sensitive areas, however, a partial biopsy may be performed without altering MRS and recurrence-free survival.