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A meta-analysis of clinical predictors for renal recovery and overall mortality in acute kidney injury requiring continuous renal replacement therapy

Journal of Critical Care Jul 21, 2020

Hansrivijit P, Yarlagadda K, Puthenpura MM, et al. - This meta-analysis was performed to define clinical predictors for continuous renal replacement therapy (CRRT) cessation in patients encountering acute kidney injury (AKI). Experts explored Ovid MEDLINE, EMBASE, and Cochrane Library. The criteria included non-end-stage kidney disease adults who needed CRRT for AKI. The analyses were grouped into renal recovery cohort and overall mortality cohort. The analyzed studies were observational. Findings revealed a higher probability of renal recovery in correlation with urine output at CRRT cessation, lower initial SOFA score, and lower serum creatinine levels at CRRT start. Increased overall death from AKI on CRRT was reported in relation to rising age and the presence of sepsis. However, on account of limited data on co-morbidities, their inclusion in the analysis might be precluded.

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