Hu Y, et al. - Researchers sought to assess the clinicopathological and prognostic value of epithelial cell adhesion molecule (EpCAM) expression in prostate cancer (PCa) via a meta-analysis. From The Cancer Genome Atlas, seven studies were identified in which immunohistochemistry was used and 871 prostatic tissue samples were included. PCa samples displayed significantly higher EpCAM expression vs benign and normal tissue samples. Findings suggest a possible correlation of EpCAM overexpression with the development of bone metastasis and worse biochemical recurrence free-survival of PCa. A significant correlation with Gleason score and bone metastasis was seen by EpCAM overexpression, which was also significantly correlated with 5-year worse biochemical recurrence free-survival, in multivariate Cox proportional-hazards regression analysis.