Ichkhanian Y, Vosoughi K, Diehl DL, et al. - The outcomes of the  full-thickness resection device (FTRD) among its early users in the USA have been described. They assessed a total of 95 patients (mean age 65.5 ± 12.6 year, 38.9% F) who underwent endoscopic full-thickness resection (EFTR) for lower gastrointestinal tract lesions using the FTRD at 26 US tertiary care centers between October 2017 and December 2018. FTRD was used most commonly in relation to the following indications: resection of difficult adenomas (non-lifting, recurrent, residual, or involving appendiceal orifice/diverticular opening) (66.3%), adenocarcinomas (22.1%), and subepithelial tumors (SET) (11.6%). This first US multicenter study suggests EFTR with the FTRD as a technically feasible, safe, and effective aproach for resecting difficult colonic lesions. In 82.7%, they attained R0 resection while in 84.2%, technical success was reported. They identified FTR histologically in 88.1% of patients.