Dong SQ, et al. - The efficacy and safety of vonoprazan (VPZ) vs proton-pump inhibitor (PPI) for Helicobacter pylori (H. pylori) eradication were evaluated in this meta-analysis. In first-line H. pylori triple eradication therapies, the efficacy of VPZ was superior to PPI, but not in second-line therapies. The safety of VPZ -containing regimens seemed similar or even superior to that of PPI. Most reports included in this study, however, had low levels of evidence. Therefore, to support the results, adequate and high-quality RCTs would be needed.