Gollub RL, et al. - Researchers performed this functional magnetic resonance imaging (fMRI) study to investigate the brain networks underlying expectancy in participants with chronic pain due to knee osteoarthritis (OA) after verum (genuine) and sham electroacupuncture (EA) treatment before and after experiencing calibrated experimental heat pain using a well-tested expectancy manipulation model. Based on findings, it seemed that in knee OA patients, expectancy modulated the experience of pain but could work through different pathways depending on the treatment modality and, they speculated, on pathophysiological states of the participants.