Chen X, et al. - The microRNAs (miRNAs) that are related to lymph node metastasis (LNM) and prognosis in breast cancer patients were studied. Poorer overall survival (OS) and disease-free survival (DFS) were found in patients with high-risk scores compared to those with low-risk scores. The miRNA signature was discovered to be an independent prognostic factor. Findings illustrated that miR-191 increased, whereas miR-214–3p, miR-451a, and miR-489 inhibited cell proliferation, migration, and invasion abilities. Thus, a four-miRNA signature could serve as a reliable prognostic and predictive tool for metastasis and survival in breast cancer patients.