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A double blind randomized controlled trial to assess efficacy of bromocriptine in cirrhotic patients with hepatic Parkinsonism

Liver International Dec 20, 2018

Sahney A, et al. - Authors studied 1016 cirrhosis cases who were given placebo or bromocriptine for 12 weeks to evaluate the effectiveness of bromocriptine in cirrhotic patients with hepatic Parkinsonism. They observed an improvement in rigidity, tremors, bradykinesia, and gait with bromocriptine therapy as compared to placebo with complete and partial response in 7 vs none and 12 vs 1 patient under MELD score, arterial NH3, and frequency of portosystemic shunts. They noted no major side-effects in either treatment group. They suggested bromocriptine, a safe and effective therapy in mild to moderate hepatic Parkinsonism.
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