Jardim JF, et al. - With regard to the prognosis, authors attempted to investigate the impact of intratumoral and peritumoral dendritic cells (DCs) in oral squamous cell carcinoma (OSCC) influencing the tongue and floor of the mouth, using immunohistochemistry for CD1a and CD83. Observations revealed that the depletion of peritumoral CD1a+ cells was related to lymph node metastasis. On the other hand, the depletion of peritumoral CD83+ cells appeared to be associated with smoking history, lymph node metastasis and extracapsular spread of lymph nodes. The survival analysis with the Cox proportional hazard model demonstrated that depletion of peritumoral CD1a+ cells served as a strong independent prognostic factor speculated higher recurrence rates and worse survival outcomes.