Juonala M, et al. - Using data from two independent population-based studies, researchers focused on how circulating metabolites were linked with carotid intima-media thickness (cIMT) and arterial pulse wave velocity (PWV). From the CheckPoint study (Australia), they analyzed 1,178 children (age 11–12 years, 51% female) and 1,316 parents (mean age 45 years, 87% female) for cross-sectional links with cIMT and PWV. From ALSPAC (The Avon Longitudinal Study of Parents and Children; UK), they analyzed longitudinal links in 4,249 children (metabolites at 7–8 years, PWV at 10–11 years, 52% female), and cross-sectional links in 4,171 of their mothers (mean age 48 years, cIMT data). Findings revealed no consistent association of circulating metabolites with cIMT and PWV in children, after adjusting for body mass index and blood pressure. Results revealed some evidence of metabolite links with PWV in their middle-aged parents. Glucose was positively, and some high-density lipoprotein-cholesterol derived measures and amino acids (glutamine, histidine, tyrosine) inversely associated with PWV among CheckPoint adults.