Mu JJ, et al. - In this prospective, randomised, controlled trial including 67 healthy patients undergoing anaesthesia induction with target-controlled infusion of propofol for elective hemithyroidectomy, researchers compared the titration method (stepwise increases in effect-site concentration until the patient loses consciousness) to the standard method (setting a high effect-site concentration target and observing the calculated effect-site concentration at loss of consciousness) in terms of difference between effect-site concentration at loss of consciousness and at recovery of consciousness. Findings revealed that, closer matching of propofol concentration to depth of anaesthesia was allowed by the titration method vs the standard method for target-controlled infusion propofol at induction of anaesthesia, when the modified Marsh pharmacokinetic model was used.