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A comparison of the bacterial nasal microbiome in allergic rhinitis patients and after immunotherapy

The Laryngoscope Mar 26, 2020

Bender ME, Read TD, Edwards TS, et al. - In view of immunological changes in allergic rhinitis (AR) and after allergen immunotherapy (IT), researchers conducted this cross‐sectional study to assess the nasal microbiome in these conditions. Nasal swabs for microbiome analysis were obtained from three patient groups: IT‐naïve AR patients, AR patients undergoing IT for greater than 12 months, and a control group without sinonasal inflammatory disease. For 14 IT‐naïve AR patients, 20 post‐IT patients, and 17 controls, nasal swabs were successfully obtained. The most prevalent bacteria across all groups were Corynebacterium and Staphylococcus. According to findings, β‐diversity between the three groups was found to be significantly different, but the AR groups were found to be more comparable to each other than to controls. While the AR group undergoing IT is experiencing symptomatic improvement, the microbiome does not tend to migrate to a healthy composition of microbiomes.

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