McCarthy D, et al. - In this randomised controlled trial, experts aspired to explore whether local infiltration analgesia (LIA), an effective pain management technique, provides better analgesia for patients undergoing unilateral total knee arthroplasty (TKA) than intrathecal morphine. Spinal anaesthesia with intrathecal bupivacaine and 0.3 mg preservative-free morphine was received by the control group whereas intervention group received opioid-free spinal anaesthesia with bupivacaine, followed by intra-operative infiltration of the knee with levobupivacaine 2 mg kg⁻¹ and adrenaline 0.5 mg diluted to a volume of 100 ml with 0.9% saline. The study was completed by 43 patients. Compared to intrathecal morphine 0.3 mg at 24 and 48 h following TKA, LIA conferred superior analgesia.