Gatto L, et al. - Researchers compared the efficacy of manual thrombus aspiration vs local drug delivery of abciximab on prestenting and poststenting thrombus burden as calculated by optical coherence tomography. Patients enrolled in the COCTAIL II study with ST elevation myocardial infarction were randomized to intralesion (IL, by the ClearWay catheter) vs intracoronary (IC, by the guide catheter) abciximab bolus with or without aspiration thrombectomy (AT). Both prestenting and poststenting thrombus burden removal was found to be comparable with either local drug delivery of abciximab or manual thrombus aspiration.