Kook H, et al. - Given both repeat stenting and drug-coated balloons (DCB) have been advised by current guidelines for the treatment of in-stent restenosis (ISR) lesions, if technically feasible, but real-world clinical data regarding the interventional strategies among patients having left main bifurcation (LMB)-ISR have not been elucidated, therefore, researchers performed a retrospective review of 75 patients with LMB-ISR, who were treated with percutaneous coronary intervention (PCI) between January 2009 and July 2015 (repeat drug eluting stent [DES] implantation [n = 51], DCB angioplasty [n = 24]). The study of baseline features revealed a lower incidence of non-ST segment elevation myocardial infarction/ST segment elevation myocardial infarction at the index PCI, higher low-density lipoprotein-cholesterol level, and more “stent-in-stent” lesions among patients in the DCB group vs those in the DES group. The DCB group vs the DES group had a smaller post-procedural minimal target lesion lumen diameter. Both groups had similar cumulative incidence rates of major adverse cardiac events (MACEs). The true bifurcation of ISR was identified as an independent risk predictor of MACEs in the multivariate Cox regression analysis. Overall, findings revealed comparable long-term clinical outcomes of DES and DCB in patients with LMB-ISR lesions.