Colombo-Barboza MN, Colombo-Barboza LR, Colombo-Barboza MMN, et al. - Researchers conducted this prospective, comparative, consecutive, blinded, nonrandomized study to compare laser in situ keratomileusis flaps created at the programmed target thickness of 120 μm using the LenSx multifunctional and the FS200 single-functional femtosecond lasers as assessed by anterior segment optical coherence tomography (AS-OCT). Consecutively, patients with stable refraction for over a year were assigned to the LenSx group or the FS200 group (n = 66; 33 patients in each group). AS-OCT flap thickness differed significantly from the target thickness at 2 of 20 points (mean differences of 2.106 and 1.803 μm) in the LenSx group. Six of 20 measurements differed significantly (mean differences ranging from 1.121 to 2.121 μm) in the FS200 group. Both femtosecond lasers were safe and able to produce highly reproducible, uniform, and regular flaps at the target preoperative thickness of 120 μm. The LenSx multifunctional femtosecond laser provides the advantage of enabling both cataract and corneal surgeries.