Liao F, et al. - As there are only a few reports referring to patients’ methicillin-resistant S. aureus (MRSA) infections in Yunnan province, southwest China, researchers here selected representative MRSA strains from patients’ systemic surveillance in Yunnan province of China, performed the genomic sequencing and compared their features, together with some food-derived strains. They selected 60 isolates for this work; of these, 40 strains were isolated from patients, and twenty isolated from food. The three major MRSA clones identified in the Yunnan province of China were ST239-t030, ST59-t437, and ST6-t701. For a number of years, ST239-t030 clonal Yunnan isolates illustrated the local endemic of clone establishment, whereas ST59-t437 strains exhibited the multi-origins of this clone. In general, the genomic study on epidemic clones of MRSA in southwest China presented the characteristics and evolution of this pathogen.