Park MJ, et al. - In patients with vitiligo, researchers conducted this prospective intra-patient comparison trial to compare effectiveness, patient satisfaction, and safety between the conventional 308-nm excimer laser (EL) and gain-switched 311-nm titanium:sapphire lasers (TSL). For this investigation, the 13-paired lesions from 10 individuals who had small vitiligo patches have been involved. After 12 weeks, all lesions treated showed improvement of around 50%. With regard to safety, there were no serious adverse effects that would require termination of treatments. The gain-switched 311-nm TSL demonstrated comparable effectiveness to the 308-nm EL in treating vitiligo and improved safety. The 311-nm TSL, therefore, is considered as a candidate device to replace the EL as a new, effective treatment option for localized vitiligo.