Tang S, et al. - This paper probed into the variations in bacterial pathogens in acute neonatal bacterial conjunctivitis, occurring from 2002 to 2016 in Southern China. A trend analysis of the bacterial pathogens in the conjunctival sac secretions of the acute neonatal bacterial conjunctivitis patients was gained through this research, in Southern China in recent years. Beneficial information could be yielded through the findings, in terms of the therapeutic options for neonatal bacterial conjunctivitis.